Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682976 | 0.80 | NOD1 (0.40) | NPSR1RAB9ATNFCXCL8SOS1 | |
| SCHEMBL9701321 | 0.78 | TBXA2R (0.53) | NPSR1RAB9ATNFCXCL8SOS1 | |
| SCHEMBL20715514 | 0.76 | NPSR1 (0.45) | NPSR1RAB9ATNFCXCL8SOS1 | |
| SCHEMBL13508713 | 0.72 | CYP11B1 (0.62) | NPSR1TNFKMT2AMEN1MAPT | |
| SCHEMBL9681247 | 0.72 | ENPP2 (0.46) | NPSR1KMT2AMEN1MAPTTP53 | |
| SCHEMBL32684880 | 0.70 | BRD4 (0.50) | NPSR1TNFKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28969544 | 0.70 | HDAC3 (0.59) | NPSR1RAB9ATNFCXCL8SOS1 | |
| SCHEMBL30995589 | 0.70 | SMN1; SMN2 (0.50) | NPSR1RAB9AMAPTNPC1TP53 | |
| SCHEMBL22465579 | 0.70 | DRD2 (0.46) | NPSR1KMT2ASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL9683089 | 0.69 | TBXA2R (0.73) | TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |