Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681416 | 0.91 | KMT2A (0.58) | KMT2AMEN1POLBADRB2SMN1; SMN2 | |
| SCHEMBL9682518 | 0.89 | SMN1; SMN2 (0.53) | KMT2AMEN1POLBADRB2SMN1; SMN2 | |
| SCHEMBL9680606 | 0.83 | TP53 (0.45) | POLBSMN1; SMN2MAPTTSHRALOX15 | |
| SCHEMBL9683234 | 0.81 | MEN1 (0.52) | KMT2AMEN1POLBADRB2SMN1; SMN2 | |
| SCHEMBL9763064 | 0.81 | KHK (0.51) | KMT2AMEN1SMN1; SMN2ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL9681944 | 0.80 | KHK (0.50) | KMT2AMEN1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL9681940 | 0.79 | KHK (0.48) | KMT2AMEN1SMN1; SMN2NPC1LMNA | |
| SCHEMBL16260557 | 0.79 | MEN1 (0.53) | KMT2AMEN1POLBADRB2SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9681236 | 0.77 | LMNA (0.44) | KMT2AMEN1POLBADRB2SMN1; SMN2 | |
| Fumaric Acid SCHEMBL9681228 | 0.77 | LMNA (0.44) | KMT2AMEN1POLBADRB2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |