Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | IDE | P14735 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681416 | 0.84 | KMT2A (0.58) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL9680660 | 0.83 | PTGER1 (0.43) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL9682148 | 0.81 | KMT2A (0.52) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL9681356 | 0.79 | DRD2 (0.47) | KMT2AMAPTTSHRHSD17B10ALDH1A1 | |
| SCHEMBL9682518 | 0.78 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| Hydrochloric Acid SCHEMBL9683227 | 0.78 | DRD2 (0.46) | KMT2AMAPTHSD17B10ALDH1A1HTR3E | |
| SCHEMBL12786109 | 0.75 | KMT2A (0.70) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL9680378 | 0.74 | ADRB1 (0.58) | MEN1KMT2AMAPTTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL9681936 | 0.73 | ADRB1 (0.56) | MEN1KMT2AMAPTTSHRHSD17B10 | |
| SCHEMBL4095953 | 0.72 | MEN1 (0.67) | MEN1KMT2AGAAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |