Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 14/20 | 0.40 |
| ▸ | BCHE | P06276 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073600 | 0.83 | LMNA (0.51) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL9676051 | 0.79 | MEN1 (0.47) | MEN1KMT2AMAPT | |
| SCHEMBL9593493 | 0.79 | HDAC1 (0.56) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL6770006 | 0.76 | HDAC1 (0.56) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL9678025 | 0.75 | RXRA (0.46) | HDAC1HDAC6RXRARARARARB | |
| SCHEMBL5736954 | 0.74 | HDAC1 (0.47) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL9593284 | 0.74 | CYP19A1 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL11323280 | 0.73 | HDAC1 (0.55) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL9376159 | 0.72 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL6746180 | 0.72 | HDAC1 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0504695-A1 | New carboxamides, their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1992-09-23 | — | — | EP | disclosed |