Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681357 | 0.74 | POLB (0.40) | EGFRCSF1RKMT2ATSHRALDH1A1 | |
| SCHEMBL11435307 | 0.72 | MAPK1 (0.46) | EGFRCSF1RGAAKMT2AGLA | |
| SCHEMBL9682441 | 0.71 | GAA (0.36) | GAAKMT2AGLAL3MBTL1 | |
| SCHEMBL11432404 | 0.70 | TUBB4A (0.48) | EGFRCSF1RTSHRSMN1; SMN2KDR | |
| SCHEMBL11435889 | 0.70 | DYRK1A (0.35) | EGFRGAAKMT2AL3MBTL1CYP3A4 | |
| SCHEMBL5213200 | 0.69 | CHKA (0.55) | KCNH2SCN5ASCN9ACHKATSHR | |
| SCHEMBL18448120 | 0.68 | FLT1 (0.43) | EGFRCSF1RKCNH2SCN5ASCN9A | |
| SCHEMBL22453198 | 0.68 | ALDH1A1 (0.54) | KCNH2SCN5ASCN9AKMT2AL3MBTL1 | |
| SCHEMBL18483201 | 0.67 | CSF1R (0.42) | EGFRCSF1RKCNH2SCN5ASCN9A | |
| SCHEMBL11003630 | 0.67 | KCNH2 (0.41) | EGFRCSF1RKCNH2SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |