Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844722 | 0.89 | LMNA (0.51) | OPRL1KCNA5CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL6631278 | 0.89 | LMNA (0.51) | OPRL1KCNA5CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL7834836 | 0.87 | SLC6A9 (0.47) | KMT2AKCNA5CYP2D6SMN1; SMN2ALDH1A1 | |
| SCHEMBL9682087 | 0.86 | OPRL1 (0.44) | OPRL1CYP2D6ALDH1A1MAPT | |
| SCHEMBL10013282 | 0.80 | KMT2A (0.59) | KMT2AOPRL1KCNA5BRD4LTA4H | |
| SCHEMBL4524121 | 0.80 | KMT2A (0.59) | KMT2AOPRL1KCNA5BRD4LTA4H | |
| SCHEMBL9682596 | 0.78 | CYP2D6 (0.49) | KMT2ACYP2D6LMNAALDH1A1MAPT | |
| SCHEMBL19895549 | 0.77 | OPRL1 (0.44) | OPRL1KCNA5CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL19895548 | 0.77 | OPRL1 (0.44) | OPRL1KCNA5CYP2D6LMNASMN1; SMN2 | |
| SCHEMBL9683895 | 0.77 | CYP2D6 (0.55) | KMT2AOPRL1CYP2D6LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130309-A | Cardiovascular disorders | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-07-14 | — | — | US | disclosed |