Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 1/20 | 0.56 |
| ▸ | EBP | Q15125 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27200194 | 0.94 | TRAP1 (0.64) | TRAP1EBPSIGMAR1TMEM97STAT3 | |
| Bromide SCHEMBL30132765 | 0.94 | TRAP1 (0.64) | TRAP1EBPSIGMAR1TMEM97STAT3 | |
| SCHEMBL30132756 | 0.93 | TRAP1 (0.65) | TRAP1EBPSIGMAR1TMEM97STAT3 | |
| Bromide SCHEMBL7436731 | 0.85 | TRAP1 (0.52) | TRAP1CYP19A1ABCB1 | |
| Bromide SCHEMBL4260842 | 0.81 | LDHA (0.53) | SIGMAR1STAT3ATMKDM4EADRB2 | |
| Bromide SCHEMBL29880790 | 0.81 | LDHA (0.53) | SIGMAR1STAT3ATMKDM4EADRB2 | |
| Bromide SCHEMBL11851106 | 0.80 | SIGMAR1 (0.50) | TRAP1SIGMAR1KMT2A | |
| SCHEMBL30596298 | 0.80 | LDHA (0.54) | SIGMAR1STAT3ATMKDM4EADRB2 | |
| Bromide SCHEMBL11099360 | 0.79 | CHRM2 (0.52) | SIGMAR1ABCB1 | |
| SCHEMBL10526510 | 0.79 | EBP (0.68) | EBPSIGMAR1TMEM97ATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466198-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-15 | — | — | EP | disclosed |
| EP-0466197-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-15 | — | — | EP | disclosed |
| EP-0464859-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-08 | — | — | EP | disclosed |
| EP-0464858-A1 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1992-01-08 | — | — | EP | disclosed |
| US-4733002-A | Lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1988-03-22 | — | — | US | disclosed |
| EP-0163270-A2 | A lipoxygenase inhibitor | GREEN CROSS CORPORATION (JP) | 1985-12-04 | — | — | EP | disclosed |