Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ARNT | P27540 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681781 | 0.86 | MAPT (0.71) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL9683008 | 0.86 | MAPT (0.67) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL12658349 | 0.84 | MAPT (0.53) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL10353546 | 0.82 | MAPT (0.72) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL9682931 | 0.81 | MAPT (0.58) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL4542148 | 0.78 | LMNA (0.53) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL9683146 | 0.78 | MAPT (0.57) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL9681404 | 0.78 | MAPT (0.56) | MAPTTDP1L3MBTL1LMNAMEN1 | |
| SCHEMBL9683458 | 0.76 | SSTR3 (0.51) | SSTR3ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL30740584 | 0.76 | MAPT (0.49) | MAPTTDP1L3MBTL1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |