Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683176 | 0.87 | SCN9A (0.48) | SCN9AHTR1ASLC6A2SLC6A4SCN5A | |
| Hydrochloric Acid SCHEMBL9681905 | 0.86 | SCN9A (0.47) | SCN9AHTR1ASLC6A2SLC6A4SCN5A | |
| SCHEMBL9681202 | 0.85 | SCN9A (0.44) | SCN9AHTR1ASLC6A2SLC6A4SCN5A | |
| SCHEMBL9681305 | 0.82 | KHK (0.47) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL29539357 | 0.82 | HTR1A (0.43) | SCN9AHTR1ASLC6A2SLC6A4SCN5A | |
| SCHEMBL22721831 | 0.82 | HTR1A (0.43) | SCN9AHTR1ASLC6A2SLC6A4SCN5A | |
| SCHEMBL9682462 | 0.81 | KHK (0.44) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| Hydrochloric Acid SCHEMBL22721791 | 0.81 | HTR1A (0.42) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| Hydrochloric Acid SCHEMBL29539589 | 0.81 | HTR1A (0.42) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL9682493 | 0.79 | ADRB1 (0.50) | HTR1ASLC6A2SLC6A4SLC6A3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |