Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683386 | 0.79 | ADRB2 (0.53) | CYP2D6ADRB2ADRB1ADRB3MAPT | |
| SCHEMBL11035037 | 0.79 | ADRB2 (0.53) | CYP2D6ADRB2ADRB1ADRB3MAPT | |
| SCHEMBL9683304 | 0.76 | MEN1 (0.76) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9684119 | 0.76 | MEN1 (0.76) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9685457 | 0.76 | MEN1 (0.76) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9684240 | 0.76 | MEN1 (0.76) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9683310 | 0.76 | MEN1 (0.76) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9684112 | 0.76 | MEN1 (0.76) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9684245 | 0.75 | MEN1 (0.58) | CYP2D6ADRB2ADRB1ADRB3DPP4 | |
| SCHEMBL9683390 | 0.75 | CYP2D6 (0.52) | CYP2D6ADRB2ADRB1ADRB3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |