Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685018 | 0.84 | AKR1B1 (0.55) | AKR1B1CDC25AMAPTWDR5 | |
| SCHEMBL9870877 | 0.82 | ALDH1A1 (0.36) | KDM4EHPGDMAPTSMN1; SMN2P2RX7 | |
| SCHEMBL9870662 | 0.79 | LMNA (0.39) | KDM4EHPGDMAPTSMN1; SMN2 | |
| SCHEMBL25876757 | 0.74 | KDM4E (0.43) | KDM4EHPGDMAPTSMN1; SMN2FFAR1 | |
| SCHEMBL8320575 | 0.74 | ALDH1A1 (0.39) | KDM4EHPGDSMN1; SMN2P2RX7CYP11B1 | |
| SCHEMBL9870526 | 0.72 | CHRM3 (0.36) | KDM4EHPGDMAPTSMN1; SMN2 | |
| SCHEMBL11358992 | 0.71 | HSD17B10 (0.47) | — | |
| SCHEMBL4466269 | 0.70 | MDM2 (0.45) | FDFT1KDM4EHPGDCYP11B1CYP11B2 | |
| SCHEMBL8727194 | 0.68 | CDC25A (0.63) | KDM4EHPGDCDC25AMAPTSMN1; SMN2 | |
| SCHEMBL7426387 | 0.67 | ALDH1A1 (0.51) | KDM4EHPGDMAPTSMN1; SMN2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |