Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870526 | 0.91 | CHRM3 (0.36) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL9870662 | 0.90 | LMNA (0.39) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL9871624 | 0.83 | ALDH1A1 (0.38) | ALDH1A1KDM4ESMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL9684160 | 0.82 | AKR1B1 (0.42) | KDM4ESMN1; SMN2HPGDMAPTP2RX7 | |
| SCHEMBL8320575 | 0.75 | ALDH1A1 (0.39) | ALDH1A1KDM4ESMN1; SMN2HPGDNPSR1 | |
| SCHEMBL9384033 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2HPGDCYP2C9 | |
| SCHEMBL11788765 | 0.61 | KDM4E (0.38) | ALDH1A1KDM4ESMN1; SMN2HPGDCYP2C9 | |
| SCHEMBL8322814 | 0.60 | TDP2 (0.47) | ALDH1A1SMN1; SMN2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL16269466 | 0.60 | CYP11B1 (0.52) | P2RX7 | |
| SCHEMBL8993321 | 0.60 | HTR2B (0.40) | ALDH1A1SMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | claimed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |