Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686173 | 0.78 | KMT2A (0.35) | TSHRMAPK1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9685754 | 0.76 | KMT2A (0.42) | TSHRMAPK1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9684169 | 0.73 | TSHR (0.37) | TSHRMAPK1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL9700761 | 0.68 | TSHR (0.49) | TSHRMAPK1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL5583389 | 0.68 | MAPK1 (0.49) | TSHRMAPK1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL4715558 | 0.67 | ALDH1A1 (0.50) | TSHRMAPK1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3253882 | 0.67 | TSHR (0.51) | TSHRMAPK1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12056084 | 0.66 | MAPK1 (0.50) | TSHRMAPK1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3920283 | 0.66 | POLB (0.40) | KMT2ASMN1; SMN2MEN1L3MBTL1MAPT | |
| SCHEMBL12418984 | 0.65 | TSHR (0.51) | TSHRMAPK1SMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1062528-A | BENZODIAZEPINONE | HOFFMANN LA ROCHE (CH) | 1992-07-08 | — | — | CN | disclosed |
| EP-0491218-A1 | Benzodiazepinones | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-24 | — | — | EP | disclosed |