Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.31 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11412815 | 0.72 | AHR (0.49) | PGRPDE4DCNR1NTSR1OPRK1 | |
| SCHEMBL613060 | 0.65 | GABRA1 (0.44) | PDE4DCNR1NTSR1OPRK1NPC1 | |
| SCHEMBL4596854 | 0.63 | KIF11 (0.47) | GRIA1PDE3BPDE3A | |
| SCHEMBL30908764 | 0.61 | PGR (0.36) | PGRPDE4DCNR1NTSR1OPRK1 | |
| SCHEMBL10373736 | 0.59 | GABRA1 (0.30) | — | |
| SCHEMBL30908740 | 0.58 | CES1 (0.39) | PGRPDE4DCNR1NTSR1OPRK1 | |
| SCHEMBL18322204 | 0.56 | GABRA1 (0.33) | MAPT | |
| SCHEMBL1460212 | 0.55 | PGR (0.55) | PGRPDE4DGRIA1CACNG8PDE3B | |
| SCHEMBL2464690 | 0.54 | — | — | |
| SCHEMBL4435837 | 0.54 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491218-A1 | Benzodiazepinones | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-24 | — | — | EP | claimed |
| EP-0491218-A1 | Benzodiazepinones | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-24 | — | — | EP | disclosed |