Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683386 | 0.84 | ADRB2 (0.53) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| SCHEMBL11035037 | 0.84 | ADRB2 (0.53) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| SCHEMBL11373385 | 0.79 | ADRB2 (0.72) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| Oxalic Acid SCHEMBL9683314 | 0.79 | MEN1 (0.76) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| SCHEMBL10873688 | 0.77 | ADRB3 (0.68) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| SCHEMBL10873682 | 0.77 | ADRB3 (0.68) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| SCHEMBL10873694 | 0.77 | ADRB3 (0.68) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL6323975 | 0.76 | ADRB3 (0.60) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL6323970 | 0.76 | ADRB3 (0.60) | KMT2AMEN1ALDH1A1ADRB2ADRB1 | |
| SCHEMBL8605105 | 0.74 | ADRB1 (0.60) | KMT2AMEN1ALDH1A1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |