Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | PNP | P00491 | 2/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.32 |
| ▸ | HINT1 | P49773 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858125 | 0.87 | CDK1 (0.41) | CDK1CCNB1CCNE1CDK2PNP | |
| SCHEMBL9683437 | 0.85 | CYP3A4 (0.43) | NT5ECYP3A4CYP2D6FGFR1 | |
| SCHEMBL9417208 | 0.84 | CDK1 (0.43) | CDK1CCNB1CCNE1CDK2PNP | |
| SCHEMBL9684339 | 0.84 | HPRT1 (0.45) | CDK1CCNB1CCNE1CDK2PNP | |
| SCHEMBL9683747 | 0.82 | ADORA2A (0.43) | NT5ECYP3A4CYP2D6FGFR1 | |
| SCHEMBL9685484 | 0.82 | PNP (0.53) | PNPHPRT1 | |
| SCHEMBL9684345 | 0.79 | CDK1 (0.41) | CDK1CCNB1CCNE1CDK2PNP | |
| SCHEMBL9683715 | 0.78 | PNP (0.52) | PNPHPRT1 | |
| SCHEMBL28327072 | 0.78 | CDK1 (0.59) | CDK1CCNB1CCNE1CDK2HSP90B1 | |
| SCHEMBL9683394 | 0.76 | FDPS (0.41) | HSP90AA1HSP90AB1CYP3A4CYP2D6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404296-A1 | Phosphono derivatives of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1990-12-27 | — | — | EP | claimed |
| US-5166198-A | Herpes virus infections | BEECHAM P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0404296-A1 | Phosphono derivatives of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1990-12-27 | — | — | EP | disclosed |