Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | GPR4 | P46093 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9636448 | 0.92 | CHRM5 (0.52) | CHRM5CHRM1KMT2AMEN1USP2 | |
| SCHEMBL9685945 | 0.88 | NPC1 (0.40) | CHRM5CHRM1ALDH1A1NPC1SLC6A9 | |
| SCHEMBL9685729 | 0.87 | SLC6A9 (0.59) | CHRM5CHRM1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9636347 | 0.84 | HTR3E (0.48) | KMT2AMEN1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL9687078 | 0.83 | CHRM5 (0.50) | CHRM5CHRM1KMT2AMEN1USP2 | |
| Fumaric Acid SCHEMBL9634992 | 0.81 | CHRM5 (0.41) | CHRM5CHRM1ALDH1A1NPC1SLC6A9 | |
| Fumaric Acid SCHEMBL9635946 | 0.81 | SLC6A9 (0.55) | CHRM5CHRM1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9687009 | 0.80 | CHRM5 (0.49) | CHRM5CHRM1KMT2AMEN1USP2 | |
| SCHEMBL9634955 | 0.79 | CHRM5 (0.57) | CHRM5CHRM1KMT2AMEN1USP2 | |
| SCHEMBL9687066 | 0.77 | RET (0.39) | KMT2AMEN1ALDH1A1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |