Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GPR4 | P46093 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9634992 | 0.92 | CHRM5 (0.41) | NPC1ALDH1A1TP53SLC6A9CHRM5 | |
| SCHEMBL9684792 | 0.88 | CHRM5 (0.49) | NPC1ALDH1A1TP53SLC6A9CHRM5 | |
| Water SCHEMBL9541138 | 0.86 | LMNA (0.38) | TP53SLC6A9CHRM5CHRM1HIF1A | |
| SCHEMBL27525284 | 0.86 | TP53 (0.39) | TP53SLC6A9CHRM5CHRM1HIF1A | |
| SCHEMBL9685729 | 0.82 | SLC6A9 (0.59) | ALDH1A1TP53SLC6A9CHRM5CHRM1 | |
| SCHEMBL9636347 | 0.81 | HTR3E (0.48) | NPC1ALDH1A1HIF1AHTR3EHTR3B | |
| SCHEMBL9686523 | 0.81 | TP53 (0.40) | TP53SLC6A9CHRM5CHRM1HIF1A | |
| Fumaric Acid SCHEMBL9636448 | 0.81 | CHRM5 (0.52) | NPC1ALDH1A1TP53SLC6A9CHRM5 | |
| SCHEMBL9690875 | 0.80 | TP53 (0.42) | ALDH1A1TP53SLC6A9LMNA | |
| Noberastine SCHEMBL18424 | 0.76 | NR4A2 (0.45) | NPC1ALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |