Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 15/20 | 0.46 |
| ▸ | CASP1 | P29466 | 13/20 | 0.46 |
| ▸ | CASP7 | P55210 | 12/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.46 |
| ▸ | HPGD | P15428 | 9/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | USP2 | O75604 | 8/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | USP19 | O94966 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686871 | 0.86 | CYP1A2 (0.43) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL9686741 | 0.85 | CYP1A2 (0.41) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL10048250 | 0.81 | CASP1 (0.57) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL9686660 | 0.79 | HTT (0.48) | ALDH1A1HSD17B10CASP1HPGDTSHR | |
| SCHEMBL9685229 | 0.77 | USP19 (0.51) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL10678247 | 0.72 | CASP1 (0.47) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Hydrochloric Acid SCHEMBL10508297 | 0.71 | CASP1 (0.47) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL14116369 | 0.71 | CASP1 (0.54) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Pipemidic Acid SCHEMBL135557 | 0.70 | LMNA (0.82) | ALDH1A1HSD17B10CASP1HPGDCYP2C9 | |
| SCHEMBL18213618 | 0.70 | LMNA (0.68) | ALDH1A1HSD17B10CASP1HPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |