Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499441 | 0.83 | MTNR1A (0.53) | ALDH1A1KDM4EHSD17B10NPC1L3MBTL1 | |
| SCHEMBL9684718 | 0.79 | NPC1 (0.47) | ALDH1A1HSD17B10NPC1L3MBTL1ESR1 | |
| SCHEMBL7568119 | 0.75 | HDAC1 (0.41) | ALDH1A1HSD17B10NPC1L3MBTL1ESR1 | |
| SCHEMBL10662358 | 0.75 | LOXL2 (0.55) | L3MBTL1LOXL2SMN1; SMN2MAOB | |
| SCHEMBL31173757 | 0.75 | LOXL2 (0.55) | L3MBTL1LOXL2SMN1; SMN2MAOB | |
| SCHEMBL2396386 | 0.73 | LOXL2 (0.46) | ALDH1A1KDM4EHSD17B10L3MBTL1ESR1 | |
| SCHEMBL9666803 | 0.73 | CES2 (0.53) | ALDH1A1KDM4EHSD17B10OPRM1SIGMAR1 | |
| SCHEMBL30886917 | 0.71 | SMN1; SMN2 (0.57) | ALDH1A1KDM4EHSD17B10L3MBTL1LOXL2 | |
| SCHEMBL10368235 | 0.71 | LOXL2 (0.55) | KDM4ENPC1ESR1ESR2LOXL2 | |
| SCHEMBL15980824 | 0.71 | CYP2D6 (0.58) | NPC1L3MBTL1LOXL2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990008545-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | claimed |
| US-5175183-A | Antiinflammatory agents, respiratory system disorders | ABBOTT LABORATORIES (US) | 1992-12-29 | — | — | US | disclosed |
| WO-1990008545-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | disclosed |