Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499441 | 0.84 | MTNR1A (0.53) | NPC1L3MBTL1LOXL2ESR1ESR2 | |
| SCHEMBL9685844 | 0.79 | ALDH1A1 (0.46) | NPC1L3MBTL1LOXL2ESR1ESR2 | |
| SCHEMBL21148536 | 0.77 | MMP2 (0.60) | MMP2MMP9ADAM17LOXL2HDAC1 | |
| SCHEMBL31173757 | 0.74 | LOXL2 (0.55) | L3MBTL1LOXL2SMN1; SMN2MAOBAGXT | |
| SCHEMBL10662358 | 0.74 | LOXL2 (0.55) | L3MBTL1LOXL2SMN1; SMN2MAOBAGXT | |
| SCHEMBL10368235 | 0.74 | LOXL2 (0.55) | NPC1MMP2MMP9ADAM17LOXL2 | |
| SCHEMBL1806012 | 0.73 | CYP2A6 (0.50) | LOXL2HDAC1HDAC2MEN1RAB9A | |
| SCHEMBL7248298 | 0.73 | LOXL2 (0.53) | NPC1MMP2MMP9ADAM17LOXL2 | |
| SCHEMBL18415492 | 0.73 | USP2 (0.54) | NPC1MMP2ADAM17LOXL2ESR1 | |
| SCHEMBL6243293 | 0.72 | LOXL2 (0.66) | LOXL2ESR1ESR2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990008545-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | claimed |
| US-5175183-A | Antiinflammatory agents, respiratory system disorders | ABBOTT LABORATORIES (US) | 1992-12-29 | — | — | US | disclosed |
| WO-1990008545-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | disclosed |