Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 6/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16213077 | 0.92 | DPP4 (0.61) | DHFRDPP4CHRM2DRD1LMNA | |
| Hydrochloric Acid SCHEMBL10557063 | 0.89 | DHFR (0.56) | DHFRDPP4CHRM2DRD1LMNA | |
| Hydrochloric Acid SCHEMBL10551784 | 0.89 | LMNA (0.66) | DHFRDPP4CHRM2DRD1LMNA | |
| SCHEMBL10377610 | 0.88 | DPP4 (0.62) | DHFRDPP4CHRM2DRD1LMNA | |
| SCHEMBL9685657 | 0.88 | DHFR (0.48) | DHFRDPP4CHRM2DRD1LMNA | |
| Hydrochloric Acid SCHEMBL10551866 | 0.87 | DPP4 (0.61) | DHFRDPP4CHRM2DRD1LMNA | |
| SCHEMBL10377708 | 0.87 | DPP4 (0.66) | DHFRDPP4CHRM2DRD1LMNA | |
| Hydrochloric Acid SCHEMBL10548709 | 0.87 | DHFR (0.57) | DHFRDPP4CHRM2DRD1LMNA | |
| SCHEMBL10377719 | 0.86 | DPP4 (0.65) | DHFRDPP4CHRM2DRD1LMNA | |
| SCHEMBL10377337 | 0.86 | DPP4 (0.65) | DHFRDPP4CHRM2DRD1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | claimed |
| US-4840954-A | BACTERICIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-20 | — | — | US | claimed |
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| US-4840954-A | BACTERICIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-20 | — | — | US | disclosed |
| CN-86100126-A | 6, the two replacement-1-cyclopropyl of 7--1,4 dihydro-4-oxo-1, the preparation method and the application thereof of 8-naphthyridines-3-carboxylic acid | — | 1986-07-09 | — | — | CN | disclosed |