Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8751834 | 0.80 | KEAP1 (0.53) | KEAP1NFE2L2MAPTKDM4EALDH1A1 | |
| SCHEMBL9805668 | 0.78 | SMN1; SMN2 (0.45) | KEAP1NFE2L2MAPTHTTKDM4E | |
| SCHEMBL565790 | 0.77 | NQO2 (0.40) | PARP1MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL10186882 | 0.77 | NNMT (0.44) | PARP1KDM4EIKBKBCD38LMNA | |
| SCHEMBL565674 | 0.77 | LMNA (0.42) | MAPTHTTKDM4EALDH1A1HPGD | |
| SCHEMBL811340 | 0.76 | DGAT1 (0.58) | DGAT1ROCK2KEAP1NFE2L2PARP1 | |
| SCHEMBL30733977 | 0.74 | DGAT1 (0.42) | DGAT1PARP1MAPTKDM4EALDH1A1 | |
| SCHEMBL8751819 | 0.74 | CA12 (0.43) | KDM4EALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL2323641 | 0.72 | DGAT1 (0.54) | DGAT1ROCK2PARP1MAPTKDM4E | |
| SCHEMBL16182121 | 0.71 | DGAT1 (0.48) | DGAT1ROCK2PARP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0160578-B1 | 1,8-NAPHTHYRIDINE DERIVATIVES | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-11-23 | — | — | EP | disclosed |
| EP-0333020-A2 | Process for the preparation of substituted pyridines | ABBOTT LABORATORIES (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4840954-A | BACTERICIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-20 | — | — | US | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |
| EP-0160578-A1 | 1,8-Naphthyridine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1985-11-06 | — | — | EP | disclosed |