Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687969 | 0.91 | NPC1 (0.52) | NPC1RAB9AALDH1A1ALOX15LMNA | |
| SCHEMBL9688628 | 0.88 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1LMNATDP1 | |
| SCHEMBL9687992 | 0.84 | ALDH1A1 (0.39) | ALDH1A1LMNAPPARGPPARATDP1 | |
| SCHEMBL9689107 | 0.82 | TDP1 (0.41) | NPC1RAB9AALDH1A1TDP1TSHR | |
| SCHEMBL9689730 | 0.81 | ALDH1A1 (0.45) | NPC1RAB9AALDH1A1LMNANPSR1 | |
| SCHEMBL9687989 | 0.81 | ELANE (0.38) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL9690007 | 0.79 | RECQL (0.54) | NPC1RAB9AALDH1A1LMNATSHR | |
| SCHEMBL9689326 | 0.79 | NPC1 (0.54) | NPC1RAB9AALDH1A1ALOX15LMNA | |
| SCHEMBL9689136 | 0.79 | NPC1 (0.54) | NPC1RAB9AALDH1A1ALOX15LMNA | |
| SCHEMBL9690056 | 0.79 | RAB9A (0.54) | NPC1RAB9AALDH1A1ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |