Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688014 | 0.91 | NPC1 (0.47) | NPC1RAB9APPARGPPARAALOX15 | |
| SCHEMBL9690007 | 0.89 | RECQL (0.54) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9687966 | 0.85 | TAS1R3 (0.42) | NPC1RAB9APPARGPPARAALDH1A1 | |
| SCHEMBL9689112 | 0.82 | NPC1 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9690049 | 0.81 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1LMNAHTT | |
| SCHEMBL9689339 | 0.81 | MEN1 (0.36) | NPC1RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL9689136 | 0.81 | NPC1 (0.54) | NPC1RAB9APPARGPPARAALOX15 | |
| SCHEMBL9689326 | 0.81 | NPC1 (0.54) | NPC1RAB9APPARGPPARAALOX15 | |
| SCHEMBL9690056 | 0.81 | RAB9A (0.54) | NPC1RAB9APPARGPPARAALOX15 | |
| SCHEMBL9689245 | 0.78 | HPGD (0.46) | NPC1RAB9AALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |