Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7253599 | 0.80 | KMT2A (0.44) | POLBKDM4EALDH1A1PKMCUL4A | |
| SCHEMBL9575010 | 0.80 | KMT2A (0.39) | POLBKDM4ENPSR1GPR55ALDH1A1 | |
| SCHEMBL2486696 | 0.75 | CUL4A (0.47) | POLBKDM4ENPSR1GPR55ALDH1A1 | |
| SCHEMBL362159 | 0.71 | TSHR (0.63) | POLBKDM4ENPSR1GPR55ALDH1A1 | |
| SCHEMBL2484716 | 0.71 | CUL4A (0.41) | KDM4ENPSR1ALDH1A1CUL4AKMT2A | |
| SCHEMBL2323034 | 0.71 | ALDH1A1 (0.50) | POLBGPR55ALDH1A1CUL4AKMT2A | |
| SCHEMBL10973674 | 0.70 | MMP1 (0.44) | POLBKDM4EALDH1A1PKMKMT2A | |
| SCHEMBL24418978 | 0.69 | KMT2A (0.49) | POLBNPSR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL363895 | 0.69 | ALDH1A1 (0.40) | POLBALDH1A1PKMCUL4AKMT2A | |
| SCHEMBL4435828 | 0.69 | KDM4E (0.44) | POLBKDM4ENPSR1GPR55ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016184652-A9 | METHODS FOR PRODUCING METALATED ORGANIC COMPOUNDS | LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) | 2017-08-10 | — | — | WO | disclosed |
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |
| EP-0237467-A2 | Heteroaryl-oxy-beta-carboline derivatives, their preparation and use as medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-09-16 | — | — | EP | disclosed |