Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 14/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 14/20 | 0.54 |
| ▸ | TERT | O14746 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688248 | 0.99 | MTNR1A (0.55) | MTNR1AMTNR1BTERTHTR6KDM4E | |
| Hydrochloric Acid SCHEMBL9688826 | 0.98 | MTNR1A (0.52) | MTNR1AMTNR1BTERTHTR6KDM4E | |
| SCHEMBL9688376 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1BTERTKDM4EHDAC1 | |
| SCHEMBL9688428 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BTERTHTR6KDM4E | |
| SCHEMBL10474646 | 0.84 | MTNR1A (0.62) | MTNR1AMTNR1BTERTKDM4EGMNN | |
| SCHEMBL9688577 | 0.83 | MTNR1A (0.45) | MTNR1AMTNR1BHTR6KDM4EHDAC1 | |
| SCHEMBL9687538 | 0.82 | MTNR1A (0.57) | MTNR1AMTNR1BALDH1A1LMNAHPGD | |
| SCHEMBL9687679 | 0.80 | MTNR1A (0.50) | MTNR1AMTNR1BTERTHDAC1ALDH1A1 | |
| SCHEMBL9688594 | 0.79 | TP53 (0.45) | MTNR1AMTNR1BHTR6HDAC1HDAC6 | |
| SCHEMBL9687575 | 0.79 | MTNR1A (0.53) | MTNR1AMTNR1BTERTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |