Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687575 | 0.90 | MTNR1A (0.53) | MTNR1AMTNR1BTERTALDH1A1HPGD | |
| SCHEMBL9687666 | 0.87 | NAMPT (0.46) | MTNR1AMTNR1BPTGDR2ALDH1A1HPGD | |
| SCHEMBL9688802 | 0.87 | MTNR1A (0.50) | MTNR1AMTNR1BTERTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9687471 | 0.85 | ACHE (0.47) | MTNR1AMTNR1BPTGDR2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9687465 | 0.85 | ACHE (0.47) | MTNR1AMTNR1BPTGDR2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9688707 | 0.85 | MTNR1A (0.48) | MTNR1AMTNR1BTERTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9688696 | 0.85 | MTNR1A (0.48) | MTNR1AMTNR1BTERTALDH1A1HPGD | |
| SCHEMBL9687680 | 0.85 | HDAC1 (0.43) | MTNR1AMTNR1BPTGDR2TP53HDAC1 | |
| SCHEMBL10377745 | 0.83 | HTR6 (0.42) | MTNR1AMTNR1BPTGDR2TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10379354 | 0.82 | HTR6 (0.41) | MTNR1AMTNR1BPTGDR2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | disclosed |
| US-4968699-A | CENTRAL NERVOUS SYSTEM; ANTIISCHEMIC AND ANTIHYPOXIC AGENTS; ACTIVE AGAINST CEREBRAL OXYGEN DEFICIENCY | BEECHAM-WUELFING GMBH & CO. (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | disclosed |