Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688726 | 0.85 | ALDH1A1 (0.35) | HDAC8HDAC6CNR1CNR2KDM4E | |
| SCHEMBL9690017 | 0.85 | ALDH1A1 (0.35) | HDAC8HDAC6CNR1CNR2KDM4E | |
| SCHEMBL9689254 | 0.75 | MEN1 (0.43) | CNR1CNR2KDM4EALDH1A1MAPK1 | |
| SCHEMBL9688067 | 0.75 | KDM4E (0.41) | CNR1CNR2KDM4EALDH1A1MEN1 | |
| SCHEMBL9689156 | 0.73 | NPSR1 (0.32) | KDM4ELMNAMMP2MMP9 | |
| SCHEMBL9688156 | 0.70 | MAPT (0.46) | HDAC8HDAC6CNR2ALDH1A1MEN1 | |
| SCHEMBL2719704 | 0.69 | ALDH1A1 (0.51) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9689070 | 0.67 | SMN1; SMN2 (0.48) | HDAC8HDAC6CNR2ALDH1A1MEN1 | |
| SCHEMBL9688818 | 0.67 | RECQL (0.66) | ALDH1A1MAPK1MEN1KMT2ANPC1 | |
| SCHEMBL9689326 | 0.67 | NPC1 (0.54) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |