Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688067 | 0.91 | KDM4E (0.41) | MEN1KMT2AKDM4ETDP1L3MBTL1 | |
| SCHEMBL9688628 | 0.79 | ALDH1A1 (0.52) | MEN1KMT2ATDP1L3MBTL1TSHR | |
| SCHEMBL9689730 | 0.78 | ALDH1A1 (0.45) | MEN1KMT2AKDM4ETDP1L3MBTL1 | |
| SCHEMBL9688014 | 0.78 | NPC1 (0.47) | MEN1KMT2ATDP1L3MBTL1MAPK1 | |
| SCHEMBL9689107 | 0.78 | TDP1 (0.41) | MEN1KMT2AKDM4ETDP1L3MBTL1 | |
| SCHEMBL9687992 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2ATDP1L3MBTL1MAPK1 | |
| SCHEMBL9688717 | 0.75 | HDAC8 (0.38) | MEN1KMT2AKDM4EMAPK1TSHR | |
| SCHEMBL9690017 | 0.75 | ALDH1A1 (0.35) | MEN1KMT2AKDM4EMAPK1TSHR | |
| SCHEMBL9688726 | 0.75 | ALDH1A1 (0.35) | MEN1KMT2AKDM4EMAPK1TSHR | |
| SCHEMBL9687989 | 0.74 | ELANE (0.38) | MEN1KMT2AKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |