Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689254 | 0.91 | MEN1 (0.43) | KDM4ETDP1KMT2AALDH1A1MEN1 | |
| SCHEMBL9792207 | 0.78 | L3MBTL1 (0.39) | KDM4ETDP1KMT2AALDH1A1MAPT | |
| SCHEMBL9690049 | 0.78 | ALDH1A1 (0.39) | KDM4EKMT2AALDH1A1MAPTALOX12 | |
| SCHEMBL9690007 | 0.78 | RECQL (0.54) | KMT2AALDH1A1MAPTALOX12NPC1 | |
| SCHEMBL9687969 | 0.77 | NPC1 (0.52) | KMT2AALDH1A1MAPTALOX12NPC1 | |
| SCHEMBL9689112 | 0.76 | NPC1 (0.40) | KDM4ETDP1KMT2AALDH1A1MAPT | |
| SCHEMBL9690017 | 0.75 | ALDH1A1 (0.35) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL9688726 | 0.75 | ALDH1A1 (0.35) | KDM4EKMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL9688717 | 0.75 | HDAC8 (0.38) | KDM4EKMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL9687966 | 0.74 | TAS1R3 (0.42) | KMT2AALDH1A1MAPTALOX12NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |