Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27741279 | 0.86 | TOP2A (0.37) | TOP2ATOP2BNOTUMMEN1KMT2A | |
| SCHEMBL8741056 | 0.81 | TOP2A (0.40) | TOP2ATOP2BNOTUMCACNA1FPOLB | |
| SCHEMBL9564474 | 0.73 | KDM4E (0.39) | TOP2ATOP2BMEN1KMT2ACACNA1F | |
| SCHEMBL8096676 | 0.73 | TOP2A (0.47) | TOP2ATOP2BNOTUMPOLBALDH1A1 | |
| SCHEMBL3138685 | 0.71 | TOP2A (0.35) | TOP2ATOP2BNOTUMMEN1KMT2A | |
| SCHEMBL9378534 | 0.71 | MEN1 (0.59) | TOP2ATOP2BMEN1KMT2ACACNA1F | |
| SCHEMBL1345175 | 0.71 | STAT3 (0.44) | TOP2ATOP2BKMT2AMAPK1ALDH1A1 | |
| SCHEMBL10700307 | 0.71 | TOP2A (0.38) | TOP2ATOP2BNOTUMCACNA1FPOLB | |
| SCHEMBL3129868 | 0.70 | CYP11B2 (0.39) | TOP2ATOP2BNOTUMKCNH2 | |
| SCHEMBL3136241 | 0.70 | TOP2A (0.47) | TOP2ATOP2BNOTUMKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4771055-A | BACTERICIDES | WARNER-LAMBERT COMPANY (US) | 1988-09-13 | — | — | US | disclosed |
| EP-0265230-A1 | Substituted-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids, derivatives thereof, pharmaceutical compositions comprising the compounds, and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |