Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.64 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | KDM6B | O15054 | 1/20 | 0.56 |
| ▸ | KDM4A | O75164 | 1/20 | 0.56 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ASPH | Q12797 | 1/20 | 0.54 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3808424 | 0.88 | GAA (0.62) | ACLYCISD1KDM4EKDM6BKDM4A | |
| SCHEMBL7464371 | 0.87 | MEN1 (0.59) | ACLYGRIK1KDM4EKDM6BKDM4A | |
| SCHEMBL27711219 | 0.85 | KDM4E (0.52) | ACLYCISD1KDM4EALDH1A1HPGD | |
| SCHEMBL7467939 | 0.85 | GRIK1 (0.59) | ACLYGRIK1KDM4EKDM6BKDM4A | |
| SCHEMBL22836946 | 0.85 | KDM6B (0.58) | ACLYGRIK1KDM4EKDM6BKDM4C | |
| SCHEMBL14399036 | 0.83 | ALDH1A1 (0.74) | ACLYKDM4EKDM6BKDM4AKDM4D | |
| SCHEMBL14389304 | 0.81 | ACLY (0.51) | ACLYGRIK1KDM4EALDH1A1MRGPRX4 | |
| SCHEMBL29855520 | 0.81 | ACLY (0.51) | ACLYGRIK1KDM4EALDH1A1MRGPRX4 | |
| SCHEMBL1147582 | 0.81 | KDM4C (0.56) | ACLYCISD1KDM4EKDM6BKDM4A | |
| SCHEMBL4209068 | 0.81 | ACLY (0.77) | ACLYCISD1KDM4EKDM6BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259167-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2022-08-18 | — | — | US | disclosed |
| WO-2020257940-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-30 | — | — | WO | disclosed |
| EP-0506709-A1 | ARTHROPODICIDAL PYRAZOLINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-07 | — | — | EP | disclosed |
| WO-1991008207-A1 | ARTHROPODICIDAL PYRAZOLINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259167-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | APP, AQP4, BACE1 | ACLY 331/4885CISD1 2432/4885GRIK1 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.