Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966869 | 0.88 | ADRB1 (0.34) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL7184756 | 0.87 | HRH3 (0.35) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL13451176 | 0.79 | CYP3A4 (0.42) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL23231419 | 0.77 | LMNA (0.44) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL8282358 | 0.77 | LMNA (0.44) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL5153023 | 0.76 | HRH3 (0.44) | HRH3CYP2C19IGF1RCYP1A2 | |
| SCHEMBL13662800 | 0.76 | HRH3 (0.44) | HRH3CYP2C19IGF1RCYP1A2 | |
| SCHEMBL15184685 | 0.76 | HRH3 (0.44) | HRH3CYP2C19IGF1RCYP1A2 | |
| SCHEMBL3195970 | 0.76 | ADRB1 (0.39) | ADRB1ADRA2AADRB3ADRA2BADRA2C | |
| SCHEMBL970319 | 0.75 | ADRA2A (0.37) | ADRB1ADRA2AADRB3ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-B1 | BACE INHIBITORS | LILLY CO ELI (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20120323001-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278441-B2 | BACE inhibitors | ELI LILLY AND COMPANY (US) | 2012-10-02 | — | — | US | disclosed |
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120323001-A1 | BACE INHIBITORS | BACE1, BACE2, APP | ADRB1 1458/4885ADRA2A 3713/4885ADRB3 2547/4885 |
| US-20110009395-A1 | BACE INHIBITORS | BACE1, BACE2, APP | ADRB1 1458/4885ADRA2A 3713/4885ADRB3 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.