Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | BCHE | P06276 | 5/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687589 | 0.80 | KDM4E (0.40) | CA2CYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL9688930 | 0.80 | — | — | |
| SCHEMBL9027471 | 0.78 | TYR (0.43) | CYP3A4MAPTKDM4EALDH1A1TYR | |
| SCHEMBL17459905 | 0.74 | RAD52 (0.37) | CA2BCHEACHECYP3A4MAPT | |
| SCHEMBL6931597 | 0.73 | CYP3A4 (0.44) | CA2BCHECYP3A4MAPTKDM4E | |
| SCHEMBL28124933 | 0.73 | CYP3A4 (0.37) | CA2CYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL19429809 | 0.73 | CYP3A4 (0.44) | CA2BCHECYP3A4MAPTKDM4E | |
| SCHEMBL28247926 | 0.73 | LMNA (0.32) | MAPTKDM4EMEN1HTTKMT2A | |
| SCHEMBL29154290 | 0.72 | RAD52 (0.38) | CA2BCHEACHECYP3A4MAPT | |
| SCHEMBL26944534 | 0.72 | ALDH1A1 (0.41) | CA2BCHEACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |