Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA3 | P07451 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30394931 | 1.00 | MAPT (0.58) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL5770279 | 1.00 | MAPT (0.58) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL718131 | 0.91 | PKM (0.59) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL9238911 | 0.87 | MAPT (0.49) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL9689450 | 0.87 | GAA (0.57) | MAPTGAATDP1KMT2AKDM4E | |
| SCHEMBL10847801 | 0.87 | GAA (0.57) | MAPTGAATDP1KMT2AKDM4E | |
| SCHEMBL30394527 | 0.85 | MAPT (0.56) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL30812355 | 0.83 | PKM (0.57) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL6072489 | 0.83 | PKM (0.57) | MAPTGAATDP1PKMPTGS2 | |
| SCHEMBL1867644 | 0.83 | SNCA (0.56) | MAPTGAATDP1PKMPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0158211-B1 | 1,4-DIHYDROPYRIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USES AS MEDICAMENTS | LABORATORIOS DELAGRANGE S.A. (ES) | 1992-08-26 | — | — | EP | disclosed |
| EP-0158211-A2 | 1,4-Dihydropyridin derivatives, process for their preparation and their uses as medicaments | LABORATORIOS DELAGRANGE S.A. (ES) | 1985-10-16 | — | — | EP | disclosed |