Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968903 | 0.87 | POLB (0.71) | NAMPTKMT2ALMNAPOLBTDP1 | |
| SCHEMBL4908338 | 0.85 | GAA (0.69) | P2RX7KMT2ALMNAPOLBTDP1 | |
| SCHEMBL11563747 | 0.81 | NAMPT (0.77) | NAMPTKMT2ALMNAPOLBTDP1 | |
| SCHEMBL27532876 | 0.79 | KDM4E (0.51) | NAMPTP2RX7KMT2ALMNAPOLB | |
| SCHEMBL7742679 | 0.78 | NAMPT (0.68) | NAMPTKMT2ALMNATDP1CYP3A4 | |
| SCHEMBL1665313 | 0.78 | POLB (0.67) | NAMPTKMT2ALMNAPOLBMEN1 | |
| SCHEMBL5348225 | 0.78 | ALDH1A1 (0.60) | NAMPTKMT2ALMNAPOLBTDP1 | |
| SCHEMBL27775337 | 0.77 | P2RX7 (0.66) | NAMPTP2RX7KMT2ALMNAPOLB | |
| SCHEMBL9130883 | 0.76 | NPC1 (0.58) | NAMPTP2RX7LMNAGAAALDH1A1 | |
| SCHEMBL5347283 | 0.76 | KMT2A (0.63) | NAMPTKMT2ALMNAPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110511209-A | It can be used as the indole carboxamides compound of kinase inhibitor | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | disclosed |
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-103073460-B | Be applicable to treat the aromatic substance that the arylsulfonyl ylmethyl of the disease responded for the adjustment of dopamine D 3 receptor or aryl sulfonic acid amides replace | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-09 | — | — | CN | disclosed |
| CN-102112447-B | HIV integrase inhibitors from pyridoxine | AMBRILIA BIOPHARMA INC | 2013-06-26 | — | — | CN | disclosed |
| CN-103073460-A | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2013-05-01 | — | — | CN | disclosed |
| CN-101068801-B | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for the treatment of disorders which respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG | 2012-11-14 | — | — | CN | disclosed |
| CN-102112447-A | HIV integrase inhibitors from pyridoxine | AMBRILIA BIOPHARMA INC | 2011-06-29 | — | — | CN | disclosed |
| CN-101678022-A | 5-cyano-4- (pyrrolo [2,3b ] pyridin-3-yl) pyrimidine derivatives useful as protein kinase inhibitors | VERTEX PHARMA | 2010-03-24 | — | — | CN | disclosed |
| CN-101068801-A | Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for the treatment of disorders which respond to modulation of the dopamine D3 receptor | ABBOTT GMBH & CO KG (DE) | 2007-11-07 | — | — | CN | disclosed |