Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687956 | 0.89 | CASP3 (0.35) | CASP3SENP8SENP7SENP6CNR2 | |
| SCHEMBL9689827 | 0.89 | CASP3 (0.35) | CASP3SENP8SENP7SENP6CNR2 | |
| SCHEMBL9689312 | 0.83 | CASP3 (0.34) | CASP3SENP8SENP7SENP6CNR2 | |
| SCHEMBL9688728 | 0.83 | MAPK1 (0.38) | CASP3SENP8SENP7SENP6CNR2 | |
| SCHEMBL9734727 | 0.81 | CASP3 (0.31) | CASP3SENP8SENP7SENP6CNR2 | |
| SCHEMBL9688805 | 0.74 | ALDH1A1 (0.44) | CNR2THRBALDH1A1MEN1LMNA | |
| SCHEMBL9688839 | 0.70 | SMN1; SMN2 (0.44) | CNR2ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL12493344 | 0.70 | CNR2 (0.49) | CNR2ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL9689936 | 0.69 | ALDH1A1 (0.36) | ALDH1A1HPGDHSD17B10TUBB4ATUBB | |
| SCHEMBL543285 | 0.68 | CNR2 (0.38) | CNR2ALDH1A1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |