Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | RORA | P35398 | 1/20 | 0.32 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689312 | 0.92 | CASP3 (0.34) | CNR2MEN1KMT2ACASP3SENP8 | |
| SCHEMBL9689195 | 0.83 | CASP3 (0.36) | ALDH1A1CNR2MEN1KMT2ACASP3 | |
| SCHEMBL9689827 | 0.82 | CASP3 (0.35) | ALDH1A1CNR2MEN1KMT2ACASP3 | |
| SCHEMBL9687956 | 0.82 | CASP3 (0.35) | ALDH1A1CNR2MEN1KMT2ACASP3 | |
| SCHEMBL9689319 | 0.80 | TSHR (0.43) | MAPK1L3MBTL1TDP1TSHRALDH1A1 | |
| SCHEMBL9689107 | 0.76 | TDP1 (0.41) | MAPK1L3MBTL1TDP1TSHRALDH1A1 | |
| SCHEMBL9688628 | 0.75 | ALDH1A1 (0.52) | L3MBTL1TDP1TSHRALDH1A1MEN1 | |
| SCHEMBL9734727 | 0.74 | CASP3 (0.31) | CNR2CASP3SENP8SENP7SENP6 | |
| SCHEMBL9689730 | 0.73 | ALDH1A1 (0.45) | MAPK1L3MBTL1TDP1TSHRALDH1A1 | |
| SCHEMBL9792274 | 0.73 | P2RX3 (0.34) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |