Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688824 | 0.84 | TSHR (0.38) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL9792298 | 0.84 | GLA (0.32) | GLANPSR1MDM2 | |
| SCHEMBL9689213 | 0.82 | KMT2A (0.39) | GLANPSR1 | |
| SCHEMBL8812100 | 0.81 | RECQL (0.50) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL9690069 | 0.80 | MEN1 (0.34) | GLANPSR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9688851 | 0.78 | NPSR1 (0.48) | GLANPSR1 | |
| SCHEMBL9689783 | 0.78 | TSHR (0.36) | GLANPSR1CYP1A2CYP3A4TSHR | |
| SCHEMBL9689705 | 0.78 | MAPT (0.35) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL9689262 | 0.78 | CNR2 (0.36) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL9689866 | 0.78 | MAPT (0.35) | CYP1A2CYP3A4CYP2D6TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |