Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691700 | 0.93 | KDM4E (0.39) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL10966704 | 0.93 | KDM4E (0.39) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL9691896 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL11007467 | 0.86 | ALDH1A1 (0.46) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL10649530 | 0.86 | PYGL (0.39) | KDM4EALDH1A1L3MBTL1CACNA1CCACNA1F | |
| SCHEMBL9557790 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL10968855 | 0.82 | CACNA1C (0.36) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL9864858 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1GAAMAPK1KMT2A | |
| SCHEMBL9691774 | 0.81 | MAPT (0.38) | ALDH1A1GAANPSR1L3MBTL1 | |
| SCHEMBL9691603 | 0.81 | ALDH1A1 (0.36) | KDM4EALDH1A1KMT2ANPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |
| EP-0071819-A1 | Dihydropyridines with a positive inotropic activity, their use in pharmaceutical preparations, and processes for their preparation | BAYER AG (DE) | 1983-02-16 | — | — | EP | disclosed |