Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.55 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22034402 | 0.87 | SIRT5 (0.57) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL22034400 | 0.87 | SIRT5 (0.57) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL17742350 | 0.87 | SIRT2 (0.69) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL968954 | 0.85 | MGLL (0.48) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL29360756 | 0.83 | MGLL (0.51) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL8130735 | 0.82 | SIRT5 (0.58) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL12606012 | 0.82 | SIRT2 (0.53) | SIRT2SIRT1SIRT5SIRT3TGM2 | |
| SCHEMBL963655 | 0.81 | SIRT2 (0.56) | SIRT2SIRT1SIRT5SIRT3MGLL | |
| Trifluoroacetic Acid SCHEMBL7316577 | 0.81 | SIRT1 (0.57) | SIRT2SIRT1SIRT5SIRT3 | |
| Trifluoroacetic Acid SCHEMBL9324388 | 0.81 | SIRT1 (0.57) | SIRT2SIRT1SIRT5SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-01-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EEF2K, RPS6KA3, MTOR | HDAC4 980/4885HDAC3 648/4885HDAC1 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.