Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20335486 | 0.84 | ALDH1A1 (0.48) | OPRK1OPRM1OPRL1CYP3A4CYP1A2 | |
| SCHEMBL6264071 | 0.82 | OPRM1 (0.44) | OPRK1OPRM1OPRL1ADRA1ACHRM2 | |
| SCHEMBL6746146 | 0.75 | OPRM1 (0.50) | OPRK1OPRM1OPRL1SLC6A2HTR2A | |
| SCHEMBL10028023 | 0.75 | CARM1 (0.36) | MAPK1HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31469975 | 0.75 | OPRM1 (0.50) | OPRK1OPRM1OPRL1SLC6A2HTR2A | |
| SCHEMBL9690444 | 0.72 | CHRM2 (0.65) | OPRK1SLC6A2HTR2AHRH1CYP3A4 | |
| SCHEMBL28230741 | 0.70 | OPRM1 (0.49) | OPRK1OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL13150789 | 0.69 | C5AR1 (0.48) | KMT2ANPSR1 | |
| SCHEMBL15944143 | 0.66 | SLC6A2 (0.38) | OPRK1SLC6A2HTR2AHRH1CYP3A4 | |
| SCHEMBL22692403 | 0.66 | ALDH1A1 (0.42) | OPRK1OPRM1OPRL1CYP3A4ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |