Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9688314 | 0.87 | GRIN2B (0.39) | PHGDHLMNAADRB2ADRB1ADRB3 | |
| SCHEMBL9690278 | 0.81 | NPC1 (0.39) | LMNAADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL10575308 | 0.69 | LMNA (0.39) | LMNAADRB2ADRB1ADRB3KDM4E | |
| Hydrochloric Acid SCHEMBL8213970 | 0.68 | LMNA (0.58) | LMNAADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL9445109 | 0.66 | NR3C2 (0.56) | LMNAADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL9445124 | 0.66 | NR3C2 (0.56) | LMNAADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL9445112 | 0.66 | NR3C2 (0.56) | LMNAADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL23531427 | 0.65 | PTGIR (0.44) | LMNAUSP19 | |
| SCHEMBL9689666 | 0.65 | GAA (0.38) | LMNAKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL6499356 | 0.63 | LMNA (0.65) | LMNAADRB2ADRB1ADRB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |