Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9690298 | 0.82 | KCNH2 (0.47) | NPC1RAB9AMITFPKMKMT2A | |
| SCHEMBL9689666 | 0.81 | GAA (0.38) | NPC1RAB9AMITFPKMKMT2A | |
| Hydrochloric Acid SCHEMBL9689762 | 0.81 | NPC1 (0.39) | NPC1RAB9AMITFPKMADRB2 | |
| SCHEMBL9689668 | 0.81 | PHGDH (0.41) | ADRB2ADRB1KMT2ALMNAADRB3 | |
| Hydrochloric Acid SCHEMBL9688314 | 0.79 | GRIN2B (0.39) | ADRB2ADRB1KMT2ALMNAADRB3 | |
| SCHEMBL9689673 | 0.77 | NPC1 (0.39) | NPC1RAB9AMITFPKMADRB2 | |
| SCHEMBL9688308 | 0.76 | NPC1 (0.40) | NPC1RAB9AMITFPKMKMT2A | |
| Hydrochloric Acid SCHEMBL9689836 | 0.70 | NPSR1 (0.42) | RAB9AADRB2ADRB1KMT2ALMNA | |
| SCHEMBL9689620 | 0.70 | NPC1 (0.54) | NPC1RAB9AMITFPKMKMT2A | |
| Hydrochloric Acid SCHEMBL8213970 | 0.69 | LMNA (0.58) | ADRB2ADRB1KMT2ALMNAADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | claimed |
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |