Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687820 | 0.80 | TAAR1 (0.39) | TAAR1ADRA1ALMNAMEN1APEX1 | |
| SCHEMBL9689858 | 0.80 | HTR1A (0.40) | — | |
| SCHEMBL9688803 | 0.76 | MTNR1A (0.44) | TSHRCYP1A2KDM4E | |
| SCHEMBL9689688 | 0.71 | HTR2A (0.44) | HTR2ATAAR1ADRA1AKDM4EATM | |
| SCHEMBL9688896 | 0.70 | HTR2A (0.47) | HTR2ATAAR1ADRA1AKDM4EATM | |
| SCHEMBL9688536 | 0.69 | TAAR1 (0.49) | HTR2ATAAR1TSHRCYP1A2CYP3A4 | |
| SCHEMBL11816292 | 0.66 | TAAR1 (0.58) | HTR2ATAAR1ADRA1A | |
| SCHEMBL26236691 | 0.66 | HTR2A (0.56) | HTR2ATAAR1ADRA1ATSHRCYP1A2 | |
| SCHEMBL14308495 | 0.65 | TAAR1 (0.66) | TAAR1ADRA1ATSHRCYP1A2CYP3A4 | |
| SCHEMBL8303296 | 0.65 | TAAR1 (0.52) | HTR2ATAAR1ADRA1ACYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |