Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 11/20 | 0.34 |
| ▸ | NOS2 | P35228 | 11/20 | 0.34 |
| ▸ | NOS3 | P29474 | 7/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689187 | 0.82 | ROCK2 (0.37) | CHRNA7HRH3RPS6KB1TAAR1ROCK2 | |
| SCHEMBL9687808 | 0.79 | NOS1 (0.47) | MAPTNOS1NOS2NOS3ROCK2 | |
| SCHEMBL19737436 | 0.75 | CHEK1 (0.37) | CHEK1MAPTROCK2ROCK1 | |
| SCHEMBL7572921 | 0.70 | MAPT (0.47) | CHEK1MAPTNOS1NOS2NOS3 | |
| SCHEMBL9687754 | 0.67 | HTR6 (0.38) | TAAR1ROCK2 | |
| SCHEMBL7571990 | 0.66 | NOS1 (0.46) | CHEK1MAPTNOS1NOS2NOS3 | |
| SCHEMBL15828619 | 0.66 | CHEK1 (0.40) | CHEK1MAPTNOS1ROCK2ROCK1 | |
| SCHEMBL22945577 | 0.66 | CHEK1 (0.40) | CHEK1MAPTNOS1ROCK2ROCK1 | |
| SCHEMBL16741907 | 0.66 | CHEK1 (0.53) | CHEK1MAPTNOS1HRH3ROCK2 | |
| SCHEMBL28071130 | 0.65 | TAAR1 (0.59) | MAPTCHRNA7HRH3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |