Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689866 | 0.86 | MAPT (0.35) | CNR2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL9689705 | 0.86 | MAPT (0.35) | CNR2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL9689149 | 0.79 | LMNA (0.39) | CNR2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL9689977 | 0.79 | TDP1 (0.36) | CNR2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL9689996 | 0.78 | GLA (0.33) | CYP3A4TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9689183 | 0.77 | GSK3B (0.47) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9689070 | 0.75 | SMN1; SMN2 (0.48) | CNR2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL9688754 | 0.72 | RECQL (0.43) | CNR2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL9688818 | 0.72 | RECQL (0.66) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9689326 | 0.71 | NPC1 (0.54) | LMNAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |