Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP5 | P51878 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689052 | 0.84 | CASP1 (0.44) | HRH1USP2SMN1; SMN2TDP1HRH4 | |
| SCHEMBL9689531 | 0.78 | HRH1 (0.46) | HRH1USP2SMN1; SMN2TDP1KDM4E | |
| SCHEMBL9689126 | 0.72 | SLC6A4 (0.37) | TDP1KDM4EALDH1A1 | |
| SCHEMBL9688175 | 0.62 | CASP1 (0.51) | HRH1USP2SMN1; SMN2TDP1HRH4 | |
| SCHEMBL8542091 | 0.62 | HRH1 (1.00) | HRH1USP2SMN1; SMN2TDP1KDM4E | |
| Hydrochloric Acid SCHEMBL9690244 | 0.62 | CASP1 (0.50) | HRH1USP2SMN1; SMN2TDP1HRH4 | |
| SCHEMBL778188 | 0.60 | SMN1; SMN2 (1.00) | HRH1USP2SMN1; SMN2TDP1KDM4E | |
| SCHEMBL7854614 | 0.60 | SIGMAR1 (0.35) | — | |
| SCHEMBL3697500 | 0.58 | ALDH1A1 (0.39) | KDM4EALDH1A1 | |
| SCHEMBL14505381 | 0.58 | HRH1 (0.59) | HRH1USP2SMN1; SMN2TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |