Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234460 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL354611 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL195410 | 0.81 | ALDH1A1 (0.42) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL3735368 | 0.81 | RAB9A (0.45) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL3859298 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL7088775 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL71079 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| Hydrochloric Acid SCHEMBL1713917 | 0.80 | NPC1 (0.41) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL16346102 | 0.79 | NPC1 (0.40) | NPC1RAB9AALDH1A1MAPTGLA | |
| SCHEMBL7088620 | 0.78 | NPC1 (0.39) | NPC1RAB9AALDH1A1MAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499231-A1 | 9-Aminotetrahydroacridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-19 | — | — | EP | disclosed |